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Cardioscore

The polygenic DNA test to identify Coronary Artery Disease (CAD) risk

  • Identify patients who have the same risk as carriers of familial hypercholesterolemia to develop CAD even if they do not manifest traditional risk factors (e.g. do not have high LDL levels).
  • It is based on 6 million common genetic variants, each with a small effect, that combined together contribute to increase CAD risk.
  • The polygenic score has higher predictive power than traditional risk factors and is independent from family history.
  • The polygenic score is an actionable risk factor. Patient with a high polygenic score that follow a healthy life-style reduce the absolute CAD risk of 49%, showing the same risk as the average population.
  • Patients with a high polygenic score show a greater benefit of statin use, with 44% risk reduction. Those who do not have a high polygenic score showed 24% risk reduction.

Predictive power of traditional risk factors and Polygenic score in 434,837 UK Biobank participants

Adapted from Inouye et al.“Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention”,Journal of the American College of Cardiology, 2018

GENOMES FROM UK BIOBANK

GENETIC VARIANTS

% OF INCREASED RISK IDENTIFIED

Cumulative absolute risk of developing Coronary Artery Disease (CAD) in UK Biobank population stratified by different percentiles of the Polygenic Risk Score (PRS)

Prevalence gradient for Coronary Artery Disease (CAD) across the distribution of the Polygenic Risk Score in UK Biobank population. Each point represents a different percentile of the PRS distribution

The Latest from Cardioscore

At the “ESC 2019 together with World Congress of Cardiology”, held in Paris in the first week of September, Allelica presented the newly developed software to compute Polygenic Risk Score (PRS) for coronary artery diseases. The clinical value of integrating PRS in traditional risk models was also discussed.

Come to meet us in Houston, Texas, at the annual conference of the American Society of Human Genetics, the largest and most exciting human genetic conference in the world. See you at booth #200 from the 15th to the 19th of October. The meeting provides a forum for the presentation and discussion of cutting-edge science in all areas of human genetics.